منابع مشابه
GRASP65 gets the chop
astillo et al. (page 453) have identified what may be a key event in building the spindle pole body (SPB) of budding yeast. They found that the kinase Mps1p phosphorylates and thus helps organize Spc42p, an important component of the SPB central plaque. Mps1p has been a difficult protein to study, as it does double duty as a regulator of SPB structure, and as part of the spindle checkpoint sign...
متن کاملThe Spindle Gets Bigger
Although cortical nonmuscle myosin II has long been implicated in cytokinetic aspects of cell division, there has never been strong evidence that it plays a role in the organization of the mitotic spindle. ([this issue of Cell]) use a number of methods to show that cortical myosin II is in fact important for spindle assembly in higher eukaryotic cells, specifically for the complete separation o...
متن کاملThe spindle gets the Axs
is seeing the shape of things to come. In two recent papers, he addresses how cell growth influences the shape of plant organs. The first article, by Utpal Nath, Coen, and colleagues, looks at a quality of leaves often taken for granted—flatness. " Flatness is not a natural outcome of growth, " says Coen. " An organism has to coordinate lots of things to keep leaves flat. " According to the gro...
متن کاملGRASP65 controls the cis Golgi integrity in vivo
GRASP65 and GRASP55 are peripheral Golgi proteins localized to cis and medial/trans cisternae, respectively. They are implicated in diverse aspects of protein transport and structure related to the Golgi complex, including the stacking of the Golgi stack and/or the linking of mammalian Golgi stacks into the Golgi ribbon. Using a mouse model, we interfered with GRASP65 by homologous recombinatio...
متن کاملGRASP65, a Protein Involved in the Stacking of Golgi Cisternae
NEM prevents mitotic reassembly of Golgi cisternae into stacked structures. The major target of NEM is a 65 kDa protein conserved from yeast to mammals. Antibodies to this protein and a recombinant form of it block cisternal stacking in a cell-free system, justifying its designation as a Golgi ReAssembly Stacking Protein (GRASP65). One of the two minor targets of NEM is GM130, previously implic...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1563iti2